Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Giuffre Randall Michael

2. Date of Event Requiring Statement (Month/Day/Year)
12/06/2018

3. Issuer Name and Ticker or Trading Symbol
DiaMedica Therapeutics Inc. [DMAC]

(Last)

(First)

(Middle)

2 CARLSON PARKWAY, SUITE 260

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

__X__ Director	_____ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

MINNEAPOLIS, MN 55447

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Voting Common Shares, no par value per share	74,554 ⁽¹⁾	D
Voting Common Shares, no par value per share	5,165	I	See footnote ⁽²⁾
Voting Common Shares, no par value per share	21,070	I	By Spouse
Voting Common Shares, no par value per share	54,186	I	By Children

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (right to buy)	⁽³⁾	10/06/2021	Voting Common Shares	1,250	$ 17.31 ⁽⁴⁾	D
Stock Option (right to buy)	⁽⁵⁾	05/09/2022	Voting Common Shares	1,250	$ 25.58 ⁽⁴⁾	D
Stock Option (right to buy)	⁽⁶⁾	10/31/2022	Voting Common Shares	1,250	$ 24.98 ⁽⁴⁾	D
Stock Option (right to buy)	⁽⁷⁾	06/25/2023	Voting Common Shares	1,250	$ 16.1 ⁽⁴⁾	D
Stock Option (right to buy)	⁽⁸⁾	11/06/2023	Voting Common Shares	1,250	$ 12.94 ⁽⁴⁾	D
Stock Option (right to buy)	⁽⁹⁾	12/01/2025	Voting Common Shares	12,000	$ 2.26 ⁽⁴⁾	D
Stock Option (right to buy)	⁽¹⁰⁾	11/28/2026	Voting Common Shares	5,000	$ 3.91 ⁽⁴⁾	D
Stock Option (right to buy)	⁽¹¹⁾	06/19/2027	Voting Common Shares	5,000	$ 4.82 ⁽⁴⁾	D
Stock Option (right to buy)	⁽¹²⁾	04/17/2028	Voting Common Shares	3,000	$ 8.43 ⁽⁴⁾	D
Warrant	⁽¹³⁾	03/28/2020	Voting Common Shares	11,225	$ 7	D

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Giuffre Randall Michael 2 CARLSON PARKWAY SUITE 260 MINNEAPOLIS, MN 55447	X

Signatures

/s/ Amy Culbert, attorney-in-fact		12/06/2018
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes 4,146 voting common shares issuable upon settlement of deferred share units granted under the DiaMedica Therapeutics Inc. Deferred Share Unit Plan, 36,498 voting common shares held by Michael Giuffre and his wife jointly and 33,910 voting common shares held by Michael Giuffre individually.
(2)	These voting common shares held by 424822 Albert Ltd, of which Michael Giuffre has sole voting and dispositive power.
(3)	This stock option vests in 12 equal quarterly installments over three years starting on January 6, 2012.
(4)	Represents the conversion of the exercise price from CAD$ to US$ on November 30, 2018.
(5)	This stock option vests in 12 equal quarterly installments over three years starting on August 9, 2012.
(6)	This stock option vests in 12 equal quarterly installments over three years starting on January 31, 2013
(7)	This stock option vests in 12 equal quarterly installments over three years starting on September 25, 2013.
(8)	This stock option vests in 12 equal quarterly installments over three years starting on February 6, 2014.
(9)	This stock option vests in 12 equal quarterly installments over three years starting on March 1, 2016.
(10)	This stock option vests in 12 equal quarterly installments over three years starting on February 28, 2017.
(11)	This stock option vests in 12 equal quarterly installments over three years starting on September 19, 2017.
(12)	This stock option vests in 12 equal quarterly installments over three years starting on July 17, 2018.
(13)	This warrant is fully vested.

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