Preeclampsia

Preeclampsia (PE) and gestational hypertension are major pregnancy complications that contribute to high rates of mortality and morbidity in pregnant women. Both conditions are marked by elevated blood pressure, which can damage vital organs. The United States reports the highest maternal mortality rate among developed countries, and this rate is growing. These hypertensive disorders affecting 1 in 7 U.S. pregnancies and the incidence of these diseases is rising by approximately 10% annually.

Importantly, there is a significant unmet need for preeclampsia patients. Preeclampsia is estimated to occur in 5-8% of all pregnancies. Annually, PE claims the lives of approximately 76,000 pregnant women and 500,000 babies worldwide. There are 50,000 severe cases in the United States every year, and the problem is believed to be worsening. Preeclampsia rates are 60% higher among Black women, compared to White women, with a greater likelihood of developing severe disease and a significantly higher risk of mortality. For the remainder of the mother’s life, she will face a significantly higher risk of developing permanent high blood pressure, a 2-4 times greater risk of stroke, and double the risk of heart and kidney failure. Overall, there is a 2-4 fold increase in the risk of death from cardiovascular disease.