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Preeclampsia
Researchers launch clinical trial testing a new promising preeclampsia drug
2024
View PublicationPreeclampsia
The Potential of DM199 to Treat Preeclampsia
2024
Stephen Tong, Susan P. Walker, Lorianne Masuoka and Catherine A. Cluver
Preeclampsia
Maternal Vascular Physiology in Preeclampsia
2024
Styliani Goulopoulou
Preeclampsia
Nature Pre-eclampsia
2023
Evdokia Dimitriadis, Daniel L. Rolnik, Wei Zhou, Guadalupe Estrada-Gutierrez, Kaori Koga, Rossana P. V. Francisco, Clare Whitehead, Jon Hyett, Fabricio da Silva Costa, Kypros Nicolaides & Ellen Menkhorst
Preeclampsia
Pre-eclampsia
2021
Lucy C Chappell, Catherine A Cluver, John Kingdom, Stephen Tong
Stroke and Stroke Recurrences
Efficacy and safety of human urinary kallidinogenase (KLK1) for acute ischemic stroke: a meta-analysis
2020
Yuanxiang Huang, Binglei Wang, Yue Zhang, Peize Wang, Xiangjian Zhang
Stroke and Stroke Recurrences
DM199/KLK1 for AIS Review Paper
2019
Human tissue kallikrein in the treatment of acute ischemic stroke
Stroke and Stroke Recurrences
Human Tissue Kallikrein in treatment in the treatment of acute ischemic stroke
2019
Michelle Alexander-Curtis, Rick Pauls, Julie Chao, John J Volpi, Philip M Bath, and Todd A. Verdoorn
Stroke and Stroke Recurrences
Human urinary kallindinogenase (KLK1) therapy for acute ischemic stroke: Clinical efficacy and risk factors
2019
Si‐Qia Chen, Dong‐Yang Mao, Dun‐Can Wei, Wen‐Zhen He
KLK1 Mechanism of Action
Genetically modified stem cells in treatment of human diseases: Tissue kallikrein (KLK1)
2018
Marina Devetzi, Maria Goulielmaki, Nicolas Khoury, Demetrios A. Spandidos, Georgia Sotiropoulou, Ioannis Christodoulou, and Vassilis Zoumpourlis
Stroke and Stroke Recurrences
Human Urinary Kallidinogenase decreases recurrent risk and promotes good recovery
2018
Dong Han, Xin Chen, Dongmei Li, Shuang Liu, Yi Lyu, and Juan Feng
Preeclampsia
Maternal Vascular Physiology in Preeclampsia
2017
Styliani Goulopoulou
Preeclampsia
Vascular Adaptation in Pregnancy and Endothelial Dysfunction in Preeclampsia
2016
DS Boeldt and IM Bird
Stroke and Stroke Recurrences
Urinary KLK1 after thrombolytic (tPA) treatment for acute cerebral infarction
2015
Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin, China
Stroke and Stroke Recurrences
Preclinical KLK1 Mechanism for AIS
2014
Human Urinary Kallidinogenase Promotes Angiogenesis and Cerebral Perfusion in Experimental Stroke
Preeclampsia
Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions
2013
Sevvandi Senadheera, Paul P. Bertrand, T. Hilton Grayson, Leo Leader, Timothy V. Murphy, Shaun L. Sandow
KLK1 Mechanism of Action
Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing
2010
Julie Chao, Bo Shen, Lin Gao, Chun-Fang Xia , Grant Bledsoe, and Lee Chao1
1 Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
Preeclampsia
Kallikrein–Kinin System in Neovascularization
2009
Michael Bader
Preeclampsia
Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3β pathway
2008
Yu-Yu Yao, Hang Yin, Bo Shen, Robert S. Smith, Jr, Yuying Liu, Lin Gao, Lee Chao, and Julie Chao
KLK1 Mechanism of Action
Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
2007
Jane A. Mitchell Ferhana Ali Lucy Bailey Laura Moreno Louise S. Harrington
Mechanisms of Disease: the tissue kallikrein–kinin system in hypertension and vascular remodeling
2007
Paolo Madeddu, Costanza Emanueli & Samir El-Dahr
KLK1 Mechanism of Action
Mechanisms of Disease: the tissue kallikrein–kinin system in hypertension and vascular remodeling
2007
Paolo Madeddu , Costanza Emanueli, Samir El-Dahr
Preeclampsia
Akt/Protein Kinase B and Endothelial Nitric Oxide Synthase Mediate Muscular Neovascularization Induced by Tissue Kallikrein Gene Transfer
2004
Costanza Emanueli, PhD, Maria B. Salis, PhD, Sophie Van Linthout, PhD, Marco Meloni, BS, Elisa Desortes, Pharm Chem D, Jean-Sebastien Silvestre, PhD, Michel Clergue, Carlos D. Figueroa, PhD, Sergio Gadau, VMD, PhD, Gianluigi Condorelli, MD, PhD, and Paolo Madeddu, MD