Annual report pursuant to Section 13 and 15(d)

Note 3 - Summary of Significant Accounting Policies (Details Textual)

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Note 3 - Summary of Significant Accounting Policies (Details Textual) - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Jan. 01, 2019
Research Grant, Recognized, Research Activities Performed 2018 $ 621,000    
Research Grant, Recognized, Research Activities Performed 2017 593,000    
Research Grant, Recognized, Research Activities Performed 2016   $ 244,000  
Subsequent Event [Member]      
Operating Lease, Right-of-Use Asset     $ 200,000
Operating Lease, Liability, Total     $ 200,000
Research and Development Expense [Member]      
Patent Expense $ 156,000 $ 160,000  
Office Equipment [Member] | Minimum [Member]      
Property, Plant and Equipment, Useful Life 3 years    
Office Equipment [Member] | Maximum [Member]      
Property, Plant and Equipment, Useful Life 10 years    
Computer Equipment [Member]      
Property, Plant and Equipment, Useful Life 4 years